精品国产乱码久久久久久免费,午夜福利1000集合集92,欧美黑人巨大xxxxx,美女xoxo又黄动态图,黄A无码片内射无码视频,日韩欧美猛交XXXXX无码,少妇伦子伦精品无码,国产精品扒开腿做爽爽爽A片唱戏,欧美 日韩 人妻 高清 中文

實驗室（更多內容見實驗室主頁https://jiewanglab.github.io/us/index.html）以多組學檢測、生物信息學分析結合實驗驗證的交叉手段，研究疾病發生與器官再生的調控機制，主要涉及以下研究內容：

1. 檢測類器官等損傷修復模型的多組學圖譜，并開發新算法分析組學數據。

2. 多組學分析結合功能實驗揭示疾病發生與器官再生的表觀調控機制。

3.?構建調控疾病發生與器官再生的數字模型，發現有效的基因干預靶點。

?

課題組圍繞疾病發生和器官再生相關的表觀組，開發了組學整合、調控網絡重構等新方法，揭示了神經退化和再生修復的表觀調控圖譜，并部分實現了哺乳動物的視網膜再生。在Science, Nature Communications, Briefings in Bioinformatics等雜志發表多篇研究論文，包括2篇ESI高被引論文。（#共同第一作者，*共同通訊作者）

1. Hoang T^#, Wang J^#, Boyd P, Wang F, Santiago C, Jiang L, Yoo S, Lahne M, Todd LJ, Jia M, Saez C, Keuthan C, Palazzo I, Squires N, Campbell WA, Rajaii F, Payail T, Trinh V, Kim DW, Wang G, Campbell LJ, Ash J, Fischer AJ, Hyde DR^*, Qian J^*, Blackshaw S^*. Gene regulatory networks controlling vertebrate retinal regeneration. Science 2020, 370(6519):?eabb8598.
2. Wang J^#, Zibetti C^#, Shang P, Sripathi SR, Zhang P, Cano M, Hoang T, Xia S,?Ji H, Merbs S, Zack D, Handa JT, Sinha D, Blackshaw S^*, Qian J^*. ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration. Nature Communications?2018, 9(1): 1-13.
3. Jiang J^#, Li J^#, Huang S, Jiang F, Liang Y, Xu X^*, Wang J^*. CACIMAR:?cross-species analysis of cell identities, markers, regulations, and interactions using single-cell RNA sequencing data. Briefings in Bioinformatics?2024, 25(1):?bbae283.
4. Fu Y^#, Jiang F^#, Zhang X, Pan Y, Xu R, Liang X, Wu X, Li X, Lin K, Shi R, Zhang X, Ferrandon D, Liu J, Pei D, Wang J^*,?Wang T^*.?Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging. Nature Communications?2024, 15(1): 1-21.
5. Jiang J^#, Lyu P^#, Li J^#, Huang S, Tao J, Blackshaw S, Qian J, Wang J^*.?IReNA: integrated regulatory network analysis of single-cell transcriptomes and chromatin accessibility profiles. iScience?2022, 25(11): 105359.

?